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The synthesis of NO occurs when L-arginine is converted by nitric oxide synthases (NOS) in the presence of oxygen [135]

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Therefore, further persistence in the design of peptide-scale molecules capable of targeting the upregulation of osteogenesis or form functional, structurally complex and well-defined scaffolds will lead to future clinical treatment modalities ranging from tissue replacement to tissue regeneration

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These typically manifest as mild redness, swelling, or tenderness lasting 24-48 hours post-injection