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however, the same reduction in cardiovascular deaths versus a placebo could be achieved at a lower cost through alternate therapies

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doi: 10.1016/j.bbamcr.2013.08.003

These so-called gliptins increase the incretin levels and therefore prolong the post-prandial insulin action

In TRIUMPH-1, the pivotal Phase 3 general-obesity trial (2,339 participants), the topline results reported on May 21, 2026 showed average weight loss at 80 weeks of 19.0% on 4 mg, 25.9% on 9 mg, and 28.3% (70.3 lbs) on 12 mg, versus 2.2% on placebo

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