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138 Building on this, two other metaanalyses, each comprising 9 RCTs, compared exenatide (alone or with metformin) to metformin alone and reported greater reductions in weight, waist circumference, and FAI, along with improvements in SHBG and the Matsuda index, again with no increase in adverse events

Timing on retatrutide itself remains open, since it still needs sign-off from the Food and Drug Administration

Early findings are intriguing, suggesting that these medications might offer a different approach compared to traditional antidepressants like SSRIs, which primarily target serotonin

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