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Comparators of interest were placebo and other pharmacological treatments, including (specific drug listed in Table 10): Metformin Other GLP-1 RAs SGLT2 inhibitors DPP-4 inhibitors Thiazolidinediones SUs Note: All dose categories comparators were analyzed together

Bring a list of current medications and supplements

Start your intake When Semaglutide Starts Working: The First Week Most patients notice changes in appetite during days 2 to 5 of starting semaglutide injection

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The most common typically strongest in the first 48 weeks as the body adapts include: Nausea (most common, usually dose-dependent) Diarrhoea or constipation Fatigue , especially during dose escalations Mild headache Reflux and acid reflux Loss of appetite (this is the therapeutic effect, not a side effect, but it can be uncomfortable) Less common but more serious effects warranting immediate physician review include pancreatitis, gallbladder disease, and kidney issues, particularly in patients with pre-existing conditions

Semaglutide is for individuals looking for gradual and steady weight loss and those managing type 2 diabetes