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2,6675,333 mcg of total blend once daily, titrated upward gradually across an 812 week course (about 1020 units )

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On the other hand, chronic hyperglycemia due to IR leads to increased extracellular and intracellular formation of advanced glycation end products (AGEs), leading to detrimental effects, including increased oxidative stress and production of inflammatory cytokines in these brain cells (125)

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