Comparative studies reveal divergent microbial impacts: Porphyromonas gingivalis oral infection exacerbates atherosclerosis in ApoE -/- mice via gut dysbiosis and lipid abnormalities (reduced HDL/triglycerides) (111), while Bacteroides fragilis -induced dysbiosis (decreased Lactobacillaceae
12 In addition, NACA prevented acetaminophen-induced cataractogenesis in rats
Yamamoto, B.A
Potential Risks or Downsides of NAD+ Anti-Aging Injections Even though NAD+ is natural, injections still carry potential risks, including: Nausea, flushing, chest or abdominal discomfort during IV infusion Headaches or fatigue afterward Pain, bruising, or infection at injection sites Phlebitis (vein inflammation) Allergic reactions to components of the infusion Unknown long-term safety, especially with repeated high doses There are also theoretical concerns for individuals with a history of cancer because NAD+ pathways play a role in cell growth and repair
The authors suggest it may have future potential not only in skin and wound care, but also in supporting healthy aging, managing chronic inflammatory and degenerative conditions, and possibly as an adjunct approach in diseases such as COPD and cancer
However, a functional impairment of the GH reserve might also be observed in patients with low levels of glucocorticoids, such as those with secondary hypoadrenalism, which is consistent with the model of biphasic dose-dependent effects of glucocorticoids on the somatotropic axis
