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Severe cases can develop into chronic ulcers, strictures, and even perforations, significantly impacting patients quality of life and treatment compliance [4,5,6]
363 Furthermore, icariin has been found to inhibit ferroptosis in synovial cells and exert a protective effect through activation of the Xc /GPX4 axis
However, in vivo studies investigating these in human models are limited
The FDA subsequently classified AOD-9604 within Category 2 of the bulk drug substance review process, and the compound was later withdrawn from that nomination in April 2026
10 .
Huang and colleagues discovered a compound, 43 , with potent inhibitory activity, exhibiting an IC 50 value of 0.13 M, against the drug allopurinol and febuxostat, with IC 50 values of 2.93 and 0.01 M, respectively
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