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On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level
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However, excessive intake of glutathione can lead to digestive issues such as diarrhea, nausea, vomiting, abdominal pain, skin rashes or itching, and difficulty breathing