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If any of these combinations achieve regulatory approval and clinical differentiation from IV pembrolizumab monotherapy, they create a second product-hopping opportunity: prescribers transition to the combination, which has its own exclusivity, rather than to IV pembrolizumab biosimilars

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Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (often 1.5-2.5 percentage points, depending on dose) and significant weight loss (approximately 5-20% of baseline body weight, with higher percentages generally seen in non-diabetic populations with obesity)

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For detailed month-by-month breakdowns of what to expect, check out our complete guide to semaglutide weight loss results