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Clinical management aims to halt depigmentation, and to either repigment or depigment the skin, depending on the extent of disease

Several peptides being studied have mechanisms that directly address this core problem: they promote new blood vessel formation (angiogenesis), reduce the inflammatory cascade that accelerates disc breakdown, and stimulate the cellular repair processes needed to rebuild damaged disc structures

doi: 10.1089/jmf.2019.4580

Their potential mechanism of action would be the inhibition of prostaglandins and cytokines, including endothelin 1 and granulocyte macrophage colony-stimulating factor (GM-CSF), which are the main stimulators of melanin production (Ebanks et al., 2009)

Nsairat H, Alshaer W, Odeh F, Esawi E, Khater D, Bawab AA, El-Tanani M, Awidi A, Mubarak MS

Gindri IM, Ferrari G, Pinto LPS, Bicca J, et al