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In the tumor microenvironment, infiltrating CD8+ T cells produce IFN- which drives the expression of PD-L1 on lymphatic endothelial cells (LECs) (94)

This limits direct translation to subcutaneous research protocols, because the delivery route and tissue environment differ substantially [7][8]

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Administration: the injection takes seconds

FDA-Approved: The product is certified by regulatory bodies including the EU, US, and THFDA, and is also approved by the US-FDA for use in hand injections

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