It is plausible that excessive ROS from other metabolic disorders (such as obesity, insulin resistance, and elevated LDL-cholesterol and low HDL-cholesterol) can induce a state of chronic low-grade inflammation (e.g., raising IFN- and TNF-), possibly aggravating or activating vitiligo in genetically predisposed individuals, as illustrated in Figure 1
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doi: 10.1016/j.mcpro.2021.100121 75 RansohoffJDWeiYKhavariPA
