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Additionally, the increased MDA levels observed upon SYNCRIP depletion were significantly reduced following SYNCRIP restoration (Figure 3E-G), further linking SYNCRIP function to suppression of ferroptosis
135,136 The underlying mechanism is that these cells lacking IDH2 show enhanced invasive behavior due to the increase in matrix metalloproteases, which depend on the NF-B pathway
Similarly, microglial activation with lipopolysaccharide and interferon- has been proposed to activate a microglia-astrocyte-neuron lactate shuttle, particularly in response to excitotoxic stimuli (Gimeno-Bayon et al., 2014)
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