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Additionally, therapeutic strategies aimed at restoring EZR function or targeting its downstream effectors may ameliorate bile composition and flow dynamics, potentially reducing the risk of gallbladder pathologies

Available data are limited and are mostly based on case reports or post-marketing observational studies [44]

However, they work through different mechanisms and can complement each other when used thoughtfully

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In other embodiments, the formulation or composition provides a therapeutically effective amount of at least one otic therapeutic agent at the site of disease with little or no detectable systemic exposure

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