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10.1111/j.1471-4159.2004.02459.x 278 YanchevaS.IhlR.NikolovaG.PanayotovP.SchlaefkeS.HoerrR.et al (2009)

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Research areas that merit focused studies include the following: Reproductive toxicology and teratogenicity Thorough testing in two species, including multi-generation studies to identify impacts on gametes, embryo development, and offspring health

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Intrinsic efficacy is the amount of signaling response (stimulus) produced by each drug-receptor-binding event, whereas intrinsic activity is the fraction of maximal response evoked by a receptor-saturating concentration of drug in that test system