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The semaglutide side effects users reported most often in clinical trials were: Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue More than 20% of trial participants reported these side effects, with 44% reporting nausea and 30% reporting diarrhea compared to 24% or fewer for vomiting, constipation, and abdominal pain

The medication works by mimicking the action of two naturally occurring incretin hormones

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Heart Foundation senior manager for healthcare programs and clinical strategy Natalie Raffoul, who is a registered pharmacist and did not contribute to the study, said this sponsorship was not a surprise

It's FDA-approved for weight management and has demonstrated significant weight loss results in clinical trials retatrutide for weight loss