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Compared to patients with TLE, those with the TLE-D phenotype exhibit more extensive structural and functional brain abnormalities, including reduced gray matter volume in cortical and subcortical regions, cerebellar damage, and white matter microstructural changes

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There's no major human clinical trials

Acknowledgements This work was supported by Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq), Fundao de Amparo Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Financiadora de Estudos e Projetos/Rede Instituto Brasileiro de Neurocincia (FINEP) and Instituto Nacional de Cincia e Tecnologia em Excitotoxicidade e Neuroproteo (INCT-EN)

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Bruggeman B.K., Storo K.E., Fair H.M., Wommack A.J., Carriker C.R., Smoliga J.M

A 30-60 minute gap between modalities prevents direct interference with blood flow