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Paracchini V, Chang SS, Santella RM et al (2005) GSMT1 deletion modifies the levels of polycyclic aromatic hydrocarbon-DNA adducts in human sperm

AHR activation in keratinocytes, Langerhans cells, and fibroblasts upregulates the expression of antimicrobial peptides, promotes the synthesis of filaggrin and loricrin, induces the release of IL-22 and prostaglandin E2, and inhibits the production of inflammatory cytokines [142,143,144]

Tirzepatide has been associated with modest increases in resting heart rate (mean increase of 24 bpm in clinical trials), though the mechanism is unclear