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Additionally, inhibition of CD38 in the AD mouse model restored NAD + levels, decreased mitochondrial ROS production and plaque depositions in the hippocampus and cortex, and improved cognitive abilities 158

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10.1371/journal.pone.0057709 141 LiuH.-l.ChenY.CuiG.-h.ZhouJ.-f

We anticipate seeing human data in the next year, in 2026, Rajagopalan said

Despite promising findings, the lack of standardized experimental models and inconsistent GLP-1-RA dosing regimens across studies limits direct comparison and reproducibility