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This made him hesitant about the clinical value of creating antagonists to histamine, compounds able to block the hormone's action

For example, patients taking tirzepatide have seen average weight reductions of up to 22.5% of their body weight, while those on semaglutide (at the weight management dose) have averaged around 15% weight loss

Semaglutide is the top driver for prescription demand both in hospitals and retail pharmacies

Research shows it works through serotonin receptor pathways in the gut

Common side effects of Wegovy Other side effects that may occur include: Indigestion or an upset stomach Bloating, burping or gas Heartburn or acid reflux Gastritis (inflammation of the stomach lining) Gallstones Hair loss or thinning Injection site reactions, such as redness, swelling or soreness Changes in taste Low blood sugar (hypoglycaemia), particularly in people with diabetes taking insulin or sulfonylureas Uncommon side effects of Wegovy Less common side effects may include: Increased heart rate Raised pancreatic enzyme levels Delayed stomach emptying (gastroparesis) Low blood sugar in people without diabetes Increased bilirubin levels Serious side effects of Wegovy Although uncommon, some side effects require urgent medical attention

2009 Oct;5(10):749-57