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The dose escalation phase alone takes 16 to 20 weeks for most GLP-1 medications, and meaningful weight loss really begins at therapeutic doses

Cell Metabolism, 30(1), 6777.e3

Microvascular and cardiovascular outcomes according to renal function in patients treated with once-weekly exenatide: insights from the EXSCEL trial

Cardiometabolic conditions: at the highest dose, Tirzepatide has shown to improve cholesterol

Both trials used gold-standard randomized, double-blind, placebo-controlled designs

Some manufacturers on platforms like Alibaba list 1g (1,000mg) for $2,000 to $5,000, which brings the per-milligram cost down to $2 to $5