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A number of factors limit their use in therapeutics, including rapid degradation through nucleases, rapid clearance via renal filtration, and a lack of chemical diversity among others (90)

BPC-157 was isolated from gastric juice, and Sikiric's group demonstrated in animal studies that orally administered BPC-157 produces measurable effects on GI tissue and, in some models, systemic tissue

This resilience might be attributed to the fact that cats can synthesize choline in their liver, though possibly not in sufficient amounts to always meet dietary recommendations, especially during periods of metabolic stress such as weight loss