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Neurodegeneration and Inflammation Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are often accompanied by neuroinflammation, which alters neurotransmitter homeostasis and exacerbates disease progression: Inflammatory Cytokines: In conditions like Alzheimer's, elevated levels of inflammatory cytokines (e.g., TNF-, IL-1) can affect neurotransmitter synthesis and receptor function

The transition from social or impulsive alcohol use to uncontrolled compulsive drinking is hypothesized to involve increased recruitment and plasticity of corticostriatal-limbic circuitry (Koob and Volkow, 2010)

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Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions