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Therefore, caution is advised when prescribing these agents to individuals with pre-existing gallbladder conditions, despite the lack of Japan-specific evidence [13]

Prevention of cardiorenal complications and beyond With the improvement in the management of cardiovascular risk factors, a progressive decline in the annual incidence rate of cardiovascular morbidity and mortality has been observed in both the general population and the diabetic population over the past decades

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12 Weeks: Employed for studies requiring a longer observation period to detect more gradual changes or to confirm sustained effects