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In T1DM, rapid neuronal apoptosis due to oxidative stress and neuroinflammation precedes vascular changes, with retinal ganglion cell loss detected in early NPDR

Cardiovasc Diabetol (2021) 20(1):189

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In CKD patients, even though anemia develops primarily as a result of the decreased lifespan of RBCs caused by the low production of erythropoietin and iron deficiency, eryptosis seems to be a fundamental contributing factor [244,245,246]

Rodent studies also report extended healthspan outcomes

while normal dietary intake is considered safe, the effects of high-dose parenteral administration are less well studied