There can be some effects of the peripheral nervous system also, but it is mainly the brain
Quinton R, Duke VM, Robertson A, Kirk JM, Matfin G, de Zoysa PA, Azcona C, MacColl GS, Jacobs HS, Conway GS, Besser M, Stanhope RG, Bouloux PM (2001) Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization
Clinical data supports this approach
The premise of the pharmaceutical industry is that people will be on these drugs for life, but thats not the reality for most people
2009 [5] Allocati N, Masulli M, Di Ilio C, Federici L
Most patients lose 2 to 5 pounds in month one, primarily from appetite suppression leading to reduced calorie intake and some initial water weight loss