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Transcript McCall McPhereson: [00:00:00] These medications originally were meant to treat diabetes two decades ago

Follow surgeon and physical therapist guidance even if feeling better than expected

Targeted management strategies include starting with a low dose and gradually increasing it, taking the medication after meals to reduce gastrointestinal discomfort, and optimizing diet (e.g., avoiding high-fat foods) (Wharton et al., 2022)

Br J Cancer 75(8):11051110 Wagner C, Briggs WT, Cook RJ (1985) Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism

This distinction matters because different strategies address each situation

Acute pancreatitis is a recognised side effect associated with their use