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Weight loss at 24 weeks (primary endpoint): Weight loss at 48 weeks (secondary endpoint): The weight loss curves had not plateaued at 48 weeks

The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism

Glucagon-receptor agonism is the genuinely novel arm: while glucagon classically raises blood glucose, controlled glucagon-receptor activation also increases energy expenditure and drives hepatic fat oxidation, which is why the triple agonist produces such pronounced reductions in liver fat

Second, several studies showed that activation of AMPK triggers apoptosis through either a JNK- and caspase-3-dependent pathway 41 , or via suppression of protein kinase B pathway and mTOR-dependent protein synthesis, respectively 40,42

The muscle-preserving effect of resistance training becomes increasingly important as weight loss progresses