when tirzepatide doesn't work 7 Reasons You Aren't Losing Weight on Weight Loss Drugs If you’re taking a GLP-1

Shahedi K et al

Acid Reflux on Mounjaro: Why It Happens and How to Manage It Common Side Effects 05 May 2026 By Acid reflux, heartburn, and gastro-oesophageal reflux disease (GORD) are among the most commonly reported gastrointestinal complaints during GLP-1 receptor agonist treatment

It also calls constipation one of the most common reasons patients discontinue GLP-1 therapy, which is why it frames the problem as something to plan for with a provider before starting rather than react to later

Some research suggests GIP might influence food reward pathways, but this remains an active area of investigation

Ezekiel Emanuel Adults aged 65 years and older were more likely to discontinue a GLP-1 than those younger than 65 years regardless of whether they had type 2 diabetes (HR = 1.28

Ask your doctor to test blood calcium levels if you discover that your D3 levels are in the high range.There is a lot of confusion about what the ideal vitamin D3 range is