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BACKGROUND [0002] Semaglutide has a chemical structure of Formula I: [0003] Semaglutide is a long-acting GLP-1 analog developed by Novo Nordisk, which only requires subcutaneous injection once a week and is still in clinical phase III currently
[PubMed Central ID: PMC9597294]
Think of the peptide as a key and the receptor as a lock: constant use wears the mechanism, and a planned off period lets it resensitize
In this article well discuss how GST-fusion proteins and glutathione agarose beads are used to perform GST pull-down assays in order to identify protein-protein interactions
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