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doi: 10.1056/NEJMcp2000280 36 BarzilaiNHuffmanDMMuzumdarRHBartkeA

The dual receptor mechanism of tirzepatide (GIP + GLP-1) may buffer some of the dopamine-suppressing effects of pure GLP-1 agonism

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SP blocks the progression of bone erosion by suppressing osteoclast activation Articular bone erosion is a central clinical feature of RA and can occur soon after disease onset