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It plays a role in converting T4 into the active T3 hormone

Zheng, X

Mice with TrxR1/Gsr-null livers exhibit full recovery from sterile acute oxidative stress induced by surgical hepatic ischemia/reperfusion injury [108], indicating that antioxidant defenses in TrxR1/Gsr-null cells are at least not so deficient as to be at a critical lethal-threshold

If kidney function declines, dose reduction or discontinuation may be necessary

Even in trials that showed a benefit, not every participant responded the same way, and the effect was modest tone-evening not a fundamental colour change

The question we keep coming back to is the same one we have always asked