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The majority of studies suggest that reducing ghrelin levels or blocking the ghrelin receptor may reduce alcohol craving

DON is a glutamine antagonist that extensively inhibits glutamine metabolism and inactivates a variety of glutamine-metabolizing enzymes by competing for covalent binding to the active site of glutamine [73]

For that reason, modern workflows increasingly rely on ultra-high-performance liquid chromatography coupled to high-resolution accurate-mass mass spectrometry, which combines separation with accurate mass information and informative fragmentation

doi: 10.1038/s41564-022-01287-6 96 ShangY.YangD.HaY.NamK

Protein sulfenic acid formation: from cellular damage to redox regulation