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The principal sources of NADPH are from the glucose-6-phosphate dehydrogenase (G6PD) reaction in the pentose phosphate pathway and via malic enzyme which is involved in the mobilization of mitochondrial acetyl-CoA to the cytosol

Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T, et al

[21] [22] To be specific, molecular O 2 is reduced to O 2 (a ROS called superoxide) when it absorbs an excited electron released from compounds of the electron transport chain

Cancer 116 , 973989 (2017)

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