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Although unproven, nonglycemic hemodynamic effects may promote cardiovascular benefits with SGLT2i (Figure 1)

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Por lo tanto, los suplementos a base de berberina o cido clorognico pueden tener beneficios leves en glucemia o perfil lipdico al estimular GLP1 endgeno, pero su eficacia es muy baja, con limitaciones en absorcin y degradacin