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P T 41 , 164172 (2016)

If it shifts more than a centimeter, tighten the side panels

Mitochondrial dysfunction further exacerbates OS by increasing ROS production, creating a vicious cycle in neuronal cells reliant on mitochondrial activity (Rizzuto et al., 2012

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For long seasons, it can be the difference between playing through it and shutting down for six weeks. 2

p53 activation can suppress the mitochondrial tricarboxylic acid cycle and oxidative phosphorylation through inhibition of malic enzymes 1/2 or by inducing a PUMA-dependent metabolic switch (Jiang et al, 2013