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This positioning reflects awareness of the mechanistic differences between probiotic support and pharmaceutical intervention

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Of note, selective serotonergic reuptake inhibitors (SSRIs) have been shown to improve pain, depression, and overall quality of life, but only to a small extent [34]

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ACKNOWLEDGEMENTS This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grant 1126857, ideas grant 1184726 and SRF 1160076 (D.W.)), and program grant 1150083 (P.M.S.))