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Eye Health Concerns Emerging research suggests a possible link between GLP-1 use and neovascular age-related macular degeneration (AMD), a leading cause of blindness

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Pain and Suffering: This may include compensation for physical pain, emotional distress, and reduced quality of life both before and after treatment

Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

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1 Lilly expects to submit its FDA application of the new drug by the end of 2025