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While the methyl cycle requires the essential nutrients methionine, folic acid (for CH 3 -THF), and choline (as a precursor of betaine), SAM is itself not considered one
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Such a non-protein cofactor is known as a "prosthetic group." R -lipoic acid functions as a prosthetic group for the biological activity of the following multienzyme complexes: The glycine cleavage system that catalyzes the decarboxylation of glycine coupled with the addition of a methylene group (-CH 2 ) to tetrahydrofolate to form 5,10-methylene tetrahydrofolate, an important cofactor in the synthesis of nucleic acids ( Figure 3 )
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All methods in this study carried out in accordance with the Declaration of Helsinki
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