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Since the ultimate goal of the project was to produce a clinically relevant molecule that could be delivered peripherally but still exhibit pro-cognitive/anti-dementia activity, the effectiveness of both the intraperitoneal and oral delivery routes of dihexa administration were determined using the scopolamine model

Dulaglutide (brand name Trulicity) is a long-acting GLP-1 receptor agonist approved by the FDA in 2014 for adults with type 2 diabetes, and later for cardiovascular risk reduction in people with established or high cardiovascular risk

Cell 17 , 30513061 (2006)

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Pair T4 with histological staining (Masson's trichrome for collagen, -SMA immunohistochemistry for myofibroblasts) to quantify fibrosis reduction

& Jozefczak, M