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Bacteria in the gut break down carnitine to trimethylamine N-oxide (TMAO), which can promote arterial disease by increasing cholesterol deposits in the arteries and inflammation

Metabolic Regulation: Restoration of SCFA production, particularly butyrate, activates G-protein-coupled receptors (GPR41/43), inhibits the NF-B signaling pathway, and reduces the release of pro-inflammatory cytokines such as IL-6 and TNF- (Siddiqui and Cresci, 2021

Savage MO, Camacho-Hbner C, Dunger DB

ACAT PMs selectively applied these funds to SBIR projects that had already successfully competed for awards and were included in ACAT system technology roadmaps

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Skin Aging Claims Versus Systemic Anti-Aging Claims Skin aging claims can point to topical studies on photoaging and wrinkle parameters, but systemic anti-aging claims often rely on gene expression, oxidative stress, inflammation, or animal data [2], [10], 17