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Even with significant appetite suppression reducing intake by 500 to 700 calories per day, actual fat loss accumulates at one to two pounds per week

Some people experience digestive discomfort, and rare serious infections have been reported in severely immunocompromised patients

While current evidence does not establish a direct causal relationship between tirzepatide and gastrointestinal bleeding, tirzepatide's known gastrointestinal effectsincluding nausea, diarrhea, vomiting, and constipationmay indirectly contribute to conditions that cause rectal bleeding

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Those impurities might include truncated peptide sequences, deletion variants missing one or more amino acids, oxidized forms of the peptide, or residual solvents from the synthesis process