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doi: 10.1046/j.1365-2257.2000.00301.x.

It is reported to delay the onset of muscular fatigue

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

That little push can make a big difference in long-term change

Vitamin B12 is involved in homocysteine metabolism for proper energy metabolism promoting healthy energy levels

thus, insufficient intake of nutritional components containing vitamin B 12 might have caused the deficiency