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For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable

Its broad relevance across multiple biological systems makes it a key compound in regenerative and recovery-focused research frameworks

As also discussed in the FY 2021 rulemaking, Baker et al

Data availability The data supporting the findings of this study are available within the main text and from the corresponding authors upon reasonable request

doi:10.1210/jc.2006-1702