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AstraZeneca stated that it views its oral GLP-1 elecoglipron as the foundation of a broader obesity strategy, potentially including combinations with its medicines for type 2 diabetes and kidney and heart disease

The cumulative effect of age-related decline plus multiple drying medications plus GLP-1 effects can accelerate dental deterioration rapidly if unmanaged

This combined receptor activation results in a synergistic effect on body weight reduction through increased energy expenditure, decreased food intake, delayed gastric emptying, and stimulation of lipolysis

Reporting by Patrick Wingrove in New York

For many people, long-term management may involve staying on the lowest effective dose of medication alongside healthy lifestyle changes