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In summary, GLP-1 improves fasting blood glucose through its direct action on the pancreatic islets and decreases postprandial hyperglycemia through inhibition of gastric emptying, and thus reduced glucose entry into circulation (74)

By acting on GLP-1 receptors in the pancreas, it stimulates insulin release and reduces glucagon secretion, resulting in better blood sugar control

In monotherapy adult clinical trials of topiramate 50 to 200 mg per day for migraine prophylaxis, the following effects occurred more frequently in the active treatment groups than the placebo group: memory impairment (7% to 11% vs

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