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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

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For women seeking evidence-based hormonal support during the perimenopausal transition, the Estradiol Patch and Bi-Est 50/50 Cream represent routes with more favorable pharmacokinetic profiles

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