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IDPN-induced rats exhibit spontaneous tics similar to those of human TS, mainly manifested by involuntary movements of the head and stereotyped behavior

Activation of NF-B induces the expression of pro-inflammatory cytokines like TNF-, IL-1, and IL-6

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Some men notice changes within weeks, while others see gradual improvements over several months

Nevertheless, when combined with CRTH2 inhibitors, FPSZM1 not only alleviated the deficits in NSC proliferation and differentiation induced by demyelination but also further promoted dendritic and spine development