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doi: 10.1016/s0024-3205(00)00803-1

Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]

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This process, known as conjugation, ensures that harmful substances are safely eliminated from the body

The blood was centrifuged at 1,500 rpm for 20 min at 4 C