incretin and glp-1 GIP as hormones: lessons from single and double incretin receptor knockout mice Dr.Syed - GLP-1 & GIP

The findings were published in The BMJ

GIP influences not only endothelial cells but also adipose tissue and circulating triglycerides, which suggests that it may significantly impact the cardiovascular system

Improved Insulin Sensitivity: Tirzepatide enhances insulin sensitivity in peripheral tissues, allowing more efficient glucose uptake and utilization, particularly beneficial for individuals with insulin resistance, a hallmark of type 2 diabetes

Likewise, GIP receptor antagonists have been reported to induce weight loss in animal studies

The SURPASS and SURMOUNT trials have led the ADA to consider tirzepatide, along with semaglutide, to be very highly efficacious for weight loss [38]

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)